Work

Booster Infusion of T-Cell Depleted, CD34+ Enriched, Donor Cells Results in Sustained Count Recovery for Patients with Poor Graft Function Following Allogeneic Stem Cell Transplantation

Year: 2012

Type: article

Abstract: Poor graft function following allogeneic stem cell transplantation (ASCT) is defined by cytopenias in the presence of complete donor engraftment. Infusion of unselected donor hematopoietic stem cells (HSC) can improve cytopenias but may increase graft versus host disease (GVHD). Here we conducted a single institution prospective study to investigate the feasibility of using “booster” infusions of T-cell depleted, CD34+ enriched donor peripheral blood mononuclear cells mobilized using G-CSF +/- plerixafor to improve the blood counts and decrease transfusion requirements in patients with poor graft function following ASCT.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.371