Work

Antimicrobial peptide incorporated poly(2‐hydroxyethyl methacrylate) hydrogels for the prevention of Staphylococcus epidermidis‐associated biomaterial infections

Year: 2012

Type: article

Abstract: The effectiveness of the antimicrobial peptide maximin-4, the ultrashort peptide H-Orn-Orn-Trp-Trp-NH(2), and the lipopeptide C(12)-Orn-Orn-Trp-Trp-NH(2) in preventing adherence of pathogens to a candidate biomaterial were tested utilizing both matrix- and immersion-loaded poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels. Antiadherent properties correlated to both the concentration released and the relative antimicrobial concentrations of each compound against Staphylococcus epidermidis ATCC 35984, at each time point. Immersion-loaded samples containing C(12)-Orn-Orn-Trp-Trp-NH(2) exhibited the lowest adherence profile for all peptides studied over 1, 4, and 24 h. The results outlined in this article show that antimicrobial peptides have the potential to serve as an important weapon against biomaterial associated infections.

Source: Journal of Biomedical Materials Research Part A

DOI: 10.1002/jbm.a.34132

Authors: Garry Laverty, Sean P. Gorman, Brendan F. Gilmore

Institution: Queen's University Belfast

Language: English

Topic: Antimicrobial agents and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1997228131

FWCI: 1.75

Cites: 57

Cited by: 63

Related to: 10