Fingerprinting Differentiation of Astragalus membranaceus Roots According to Ages Using1H-NMR Spectroscopy and Multivariate Statistical Analysis
Year: 2009
Type: article
Abstract: The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including $\gamma$ -aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.
Source: Biomolecules & Therapeutics
Institutions: Rural Development Administration, National Institute of Horticultural and Herbal Science, Kongju National University, National Academy of Agricultural Sciences, National Academy of Agricultural Science, Seoul National University, Korea Research Institute of Bioscience and Biotechnology, Korea University, Chung-Ang University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1997446747