Work

The Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway

Year: 2013

Type: review

Abstract: Viral pathogens must overcome innate antiviral responses to replicate successfully in the host organism. Some of the mechanisms viruses use to interfere with antiviral responses in the infected cell include preventing detection of viral components, perturbing the function of transcription factors that initiate antiviral responses, and inhibiting downstream signal transduction. RNA viruses with small genomes and limited coding space often express multifunctional proteins that modulate several aspects of the normal host response to infection. One such virus, rotavirus, is an important pediatric pathogen that causes severe gastroenteritis, leading to ~450,000 deaths globally each year. In this review, we discuss the nature of the innate antiviral responses triggered by rotavirus infection and the viral mechanisms for inhibiting these responses.

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1003064

Authors: Michelle M. Arnold, Adrish Sen, Harry B. Greenberg, John T. Patton

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, VA Palo Alto Health Care System, Stanford University

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043