Work

Antibody responses toCryptococcus neoformansin Indian patients with cryptococcosis

Year: 2008

Type: article

Abstract: An important element of the host response to cryptococcosis is humoral immunity. Specific antibody responses in patients with cryptococcosis however, have not been extensively studied. We analyzed the antibody responses of 22 Indian patients with cryptococcosis, including both HIV+ and HIV- individuals. Sera from 10 Indian patients with AIDS and without cryptococcosis were studied as controls. Antibody responses to cryptococcal proteins were detected by immunoblot, while antibodies to glucuronoxylomannan (GXM), the main component of the cryptococcal capsular polysaccharide were measured by ELISA. Our results indicate that cryptococcosis elicits antibodies to a specific pattern of cytoplasmic proteins. Further, we find that antibody responses to both cytoplasmic proteins and GXM are less robust in HIV+ patients when compared with HIV- patients.

Source: Medical Mycology

DOI: 10.1080/13693780801961345

Authors: Dolan Champa Saha, Immaculata Xess, Wang Yong Zeng, David L. Goldman

Institutions: All India Institute of Medical Sciences, Albert Einstein College of Medicine

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: All-India Institute of Medical Sciences, Fogarty International Center