Work

Mitochondrial Dynamics Of Survivin And “Four Dimensional” Control Of Tumor Cell Apoptosis

Year: 2004

Type: article

Abstract: The intense investigation of cell death pathways over the past few years has uncovered elevated complexity with panoply of molecular interactions, multiple intersecting gene networks and bidirectional crosstalk among disparate cellular regulators. What has remained more elusive is how these interactions are spatially arranged in the "four dimensions" of the cell as a whole, and their true relevance to human diseases. Fresh evidence obtained with survivin has unraveled a process of dynamic subcellular shuttling that is required to inhibit apoptosis during tumor growth, with the mitochondrion playing a central, orchestrating role.

Source: Cell Cycle

DOI: 10.4161/cc.4.1.1367

Authors: Takehiko Dohi, Dario Altieri

Institution: University of Massachusetts Chan Medical School

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute