Work

Is Parkinson's disease a prion disorder?

Year: 2009

Type: article

Abstract: In this issue of PNAS, Desplats et al. (1) demonstrate that nerve cells that overexpress tagged α-synuclein can transmit the protein to neural stem cells in both in vitro and in vivo models. This important study could explain the remarkable finding that human embryonic dopamine nerve cells implanted into the striatum of patients with Parkinson's disease (PD) develop PD pathology with loss of dopamine markers and classic Lewy bodies (2, 3). It also provides insight into how α-synuclein pathology might sequentially spread throughout the nervous system in PD.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0906759106

Authors: C. Warren Olanow, Stanley B. Prusiner

Institutions: Icahn School of Medicine at Mount Sinai, University of California, San Francisco

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1997531277

FWCI: 17.27

Cites: 20

Cited by: 280

Related to: 10