Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
Year: 2000
Type: article
Abstract: The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-regulated kinase) pathway is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Although the basic regulatory steps have been elucidated, many features of this pathway are only beginning to emerge. This review focuses on the role of protein-protein interactions in the regulation of this pathway, and how they contribute to co-ordinate activation steps, subcellular redistribution, substrate phosphorylation and cross-talk with other signalling pathways.
Source: Biochemical Journal
DOI: 10.1042/bj3510289
Author: Walter KOLCH
Institution: Cancer Research UK Scotland Institute
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1997656209