Work

Transgenic Modeling of Cytokines in the Investigation of Pulmonary Disease

Year: 1996

Type: article

Abstract: Cytokine biology dates back to 1966 when J.R. David demonstrated that stimulated lymphocytes produce a soluble factor termed “migration inhibitory factor” which inhibited macrophage migration.1 This observation has been followed by an explosion of information demonstrating the existence of a large number of cytokines, the ability of virtually every nucleated cell to produce a cadre of these regulatory proteins, in vitro studies suggesting that cytokines play an important role in the regulation of virtually all aspects of biological homeostasis, and studies demonstrating that cytokines have organ-specific effects and often mediate their effects as part of complex interactive regulatory networks.

Source: CHEST Journal

DOI: 10.1378/chest.109.3_supplement.69s