Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV ‐infected women with and without central lipohypertrophy
Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Normal lipid metabolism and functioning of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study. METHODS: Hair characteristics and scalp inflammation were assessed by an interviewer-administered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors. RESULTS: There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8). CONCLUSIONS: Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.
DOI: 10.1111/ijd.12044
Institutions: Kaiser Permanente Vallejo Medical Center, University of California, San Francisco, Rush University Medical Center, Cook County Health and Hospitals System, Johns Hopkins University, University of Southern California, Georgetown University, Georgetown University Medical Center, Montefiore Medical Center, SUNY Downstate Health Sciences University, San Francisco VA Medical Center
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, University of California, San Francisco, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1047576501, G1252706584, G1360453192, G1377681116, G1383752764, G1423343497, G1440661678, Clinical and Translational Science Institute, G1653728403, G1689765846, G1919789535, G2037985070, G2210861095, G2567544100, G2574405597, G2674972404, G2690160998, G2692709432, G27852282, G3009646583, G316338625, G3212103026, G3222910550, G3264576717, G3322721267, The Connie Wofsy Women's HIV Study, Brooklyn Women's Interagency HIV Study (WIHS) V, G3634354056, G3658850503, G3901006228, G398667773, G4097647764, G4210511483, G4419450409, WIHS Data Management and Analysis Center (WDMAC), G4547062945, G4622231416, Southern California Women's Interagency HIV Study Consortium, G499585988, Chicago WIHS Consortium V (CWC), G5182092287, G5282551706, Washington Women's Interagency HIV/AIDS Study, Clinical and Translational Science Institute, G5909718580, G6295786800, G6694807131, G7195401492, G758528517, HIV and Adiposity in Women: Effects on Bone Metabolism, G7777414286, Women's Interagency HIV Study (WIHS-V), G8121648955, G826976987, G8350406629, G893076474, G8962527242, G8964979204, G9000034972, G9000058261, G9000073987, G9000166853, G9000237332, G9000338758, G90347297, G920507375, G925273713, G976727283
OpenAlex ID: W1998029417