Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging Contrast
Year: 2008
Type: article
Abstract: Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm800521j
Authors: Darren K. MacFarland, Kenneth L. Walker, Robert P. Lenk, Stephen R. Wilson, Krishan Kumar, Christopher L. Kepley, Joel R. Garbow
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G1114310655, Development of Novel Cholesteryl-Derivatized Endohedral Metallofullerenes for Ima, G12431752, Washington University Small Animal Imaging Resource, G1581683937, G1735505112, G1856342231, G2675570935, G299873027, G5100194104, G530368241, Using Nanomaterials to Inhibit Mast Cell/Basophil-Associated Disease, G815473159, G8242737674, G9000285099, G9000319192, Cancer Center Support Grant
OpenAlex ID: W1998075216