JAK/STAT signalling inDrosophila: insights into conserved regulatory and cellular functions
Year: 2006
Type: review
Abstract: High levels of interspecies conservation characterise all signal transduction cascades and demonstrate the significance of these pathways over evolutionary time. Here, we review advances in the field of JAK/STAT signalling, focusing on recent developments in Drosophila. In particular, recent results from genetic and genome-wide RNAi screens, as well as studies into the developmental roles played by this pathway, highlight striking levels of physical and functional conservation in processes such as cellular proliferation, immune responses and stem cell maintenance. These insights underscore the value of model organisms for improving our understanding of this human disease-relevant pathway.
Source: Development
DOI: 10.1242/dev.02411
Authors: Natalia I. Arbouzova, Martin P. Zeidler
Institution: Max Planck Institute for Biophysical Chemistry
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funder: Max-Planck-Gesellschaft
OpenAlex ID: W1998148517