Work

Access to Functionalized Steroid Side Chains via Modified Julia Olefination

Year: 2011

Type: article

Abstract: Various functionalized steroidal side chains were conveniently accessed by a modified Julia olefination strategy using a common sulfone donor and an appropriate α-branched aldehyde acceptor. For the coupling of these hindered classes of reaction partners (and in contrast to typically observed trends), the benzothiazolyl(BT)-sulfone anion gave superior outcomes compared to the phenyltetrazolyl(PT)-sulfone anion.

Source: Organic Letters

DOI: 10.1021/ol102936z

Authors: Enver Cagri Izgu, Aaron C. Burns, Thomas R. Hoye

Institution: University of Minnesota

Language: English

Topic: Steroid Chemistry and Biochemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences

Awards: G1073186712, G2772789463, Synthesis, Biosynthesis, and Structure of Antitumor Agents, New Strategies for Bioactive Molecule Synthesis