Work

Value of a Consensus Panel to Adjudicate Cause-Specific Mortality after Unrelated Donor Allogeneic Hematopoietic Cell Transplantation (URD-HCT) for Use As the Primary Endpoint in a Genome-Wide Association Study (GWAS)

Year: 2014

Type: article

Abstract: Cause-specific death (CSD) due to transplant-related complications (TRM) after URD-HCT is often multi-factorial. Consensus adjudication panels (CP), commonly used in clinical trials, are rarely used in observational research. Given the risk of endpoint misclassification due to CSD complexity and reporting variability, we hypothesized that a CP would uncover misclassifications that could cause confounding effects in a GWAS. A CP for CSD was developed, including 2 adult BMT physicians (MP, PLM), a pediatric oncologist (KO), and BMT epidemiologist (TH).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.024