Work

SCF-KIT Pathway in Human Epidermal Melanocyte Homeostasis

Year: 1999

Type: article

Abstract: In the August issue of the Journal of Investigative Dermatology,Grichnik et al. (1998) demonstrated the responsiveness of adult human melanocytes to stem cell factor (SCF) in vivo. We have been interested in the role of SCF in postnatal skin since we discovered the production of SCF by human keratinocytes, and noted that the presence of the soluble form of SCF is associated with locally increased pigment production in the epidermis of patients with urticaria pigmentosa (Longley et al. 1993). These observations first implicated local production of SCF in postnatal melanocyte function.

Source: Journal of Investigative Dermatology

DOI: 10.1046/j.1523-1747.1999.00643.x

Authors: B. Jack Longley, Eric L. Carter

Institution: Columbia University

Language: English

Topic: melanin and skin pigmentation

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,800