Work

A new example of a morphine‐sensitive neuro‐effector junction: Adrenergic transmission in the mouse vas deferens

Year: 1997

Type: article

Abstract: The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0*5 p ~) .This effect of morphine is mediated by specific receptors which are blocked by naloxone.Activation of the morphine receptors inhibits noradrenaline release.It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.The effects of morphine on the peripheral nervous system are very selective.For example, morphine inhibits cholinergic transmission in the guinea-pig ileum (Paton,

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1997.tb06821.x

Authors: G. Henderson, J. Hughes, H. W. Kosterlitz

Institution: University of Aberdeen

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Medical Research Council