Work

Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila

Year: 2009

Type: review

Abstract: Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.

Source: Development

DOI: 10.1242/dev.036160

Authors: Matthew J. Borok, Diana A. Tran, Margaret C. W. Ho, Robert A. Drewell

Institution: Harvey Mudd College

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Howard Hughes Medical Institute

OpenAlex ID: W1998496976

FWCI: 0.426

Cites: 75

Cited by: 53

Related to: 10