Work

Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens

Year: 2012

Type: article

Abstract: The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01197-12

Authors: Mitchell G. Thompson, Brendan W. Corey, Yuanzheng Si, David W. Craft, Daniel V. Zurawski

Institution: Walter Reed Army Institute of Research

Language: English

Topic: Antimicrobial agents and applications

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, Walter Reed Army Institute of Research