Work

Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform

Year: 2008

Type: article

Abstract: High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.

Source: Nano Letters

DOI: 10.1021/nl801958b

Authors: David P. Cormode, Torjus Skajaa, Matti M. van Schooneveld, Rolf Koole, Peter Jarzyna, Mark E. Lobatto, Claudia Calcagno, Alessandra Barazza, Ronald E. Gordon, Pat Zanzonico, Edward A. Fisher, Zahi A. Fayad, Willem J. M. Mulder

Institutions: Mount Sinai Hospital, Utrecht University, Aarhus University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Center for Research Resources

Awards: G140661078, G2104740914, G2745113313, G342219358, G3676933657, G4697278714, G51615063, MR/PET Imaging of coronary atherosclerosis, G727209760, G79279958, Cancer Center Support Grant

OpenAlex ID: W1998993589

FWCI: 10.78

Cites: 53

Cited by: 328

Related to: 10