Work

Myeloid translocation gene 16b is a dual A‐kinase anchoring protein that interacts selectively with plexins in a phospho‐regulated manner

Year: 2010

Type: article

Abstract: The myeloid translocation gene (MTG) homologue Nervy associates with PlexinA on the plasma membrane, where it functions as an A-kinase anchoring protein (AKAP) to modulate plexin-mediated semaphorin signaling in Drosophila. Mammalian MTG16b is an AKAP found in immune cells where plexin-mediated semaphorin signaling regulates immune responses. This study provides the first evidence that MTG16b is a dual AKAP capable of binding plexins. These interactions are selective (PlexinA1 and A3 bind MTG, while PlexinB1 does not) and can be regulated by PKA-phosphorylation. Collectively, these data suggest a possible mechanism for the targeting and integration of adenosine 3',5'-cyclic monophosphate (cAMP) and semaphorin signaling in immune cells.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2010.02.007

Authors: Sarah E. Fiedler, Robynn V. Schillace, Crystal J. Daniels, Sarah F. Andrews, Daniel W. Carr

Institutions: Oregon Health & Science University, Portland VA Medical Center

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

Funders: U.S. Department of Veterans Affairs, National Institute of Allergy and Infectious Diseases

Award: ANCHORING OF PROTEIN KINASE A IN T LYMPHOCYTES