Work

Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex

Year: 1999

Type: review

Abstract: The delivery of secretory vesicles to appropriate docking and fusion sites on the plasma membrane is crucial for many cellular functions, including formation of synapses, exocytosis of neurotransmitter, establishment and maintenance of cell polarity, cell growth and plasma membrane wound healing. Cell-biological, genetic and biochemical approaches have identified crucial proteins and protein interactions important for vesicle docking and fusion. However, a description of the molecular mechanisms underlying vesicle targeting to specific membrane-fusion sites remains elusive. This review discusses a set of proteins that might direct vesicles to specific domains of the plasma membrane.

Source: Trends in Cell Biology

DOI: 10.1016/s0962-8924(99)01516-0

Authors: Shu-Chan Hsu, Christopher D Hazuka, Davide L Foletti, Richard H Scheller

Institutions: Howard Hughes Medical Institute, Stanford Medicine, Stanford University

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

OpenAlex ID: W1999127875

FWCI: 1.083

Cites: 31

Cited by: 170

Related to: 10