Work

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

Year: 1996

Type: article

Abstract: Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may function as an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.22.12445

Authors: V Groh, S Bahram, S Bauer, A Herman, M Beauchamp, T Spies

Institutions: Fred Hutch Cancer Center, Yale University

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases