Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ 11 C]PiB
Year: 2010
Type: article
Abstract: OBJECTIVE: To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without dementia. METHOD: [(11)C]PiB images were obtained to measure fibrillar Abeta burden in 57 participants without dementia from the Baltimore Longitudinal Study of Aging. Participants (33 men, 24 women) had a mean (SD) age of 78.7 (6.2) years. Six participants (4 men, 2 women) had mild cognitive impairment defined as Clinical Dementia Rating = 0.5. To measure [(11)C]PiB retention, distribution volume ratios (DVR) for 15 regions of interest were estimated by fitting a simplified reference tissue model to the measured time activity curves. Mixed effects regression was used to predict cognitive trajectories over time using data before and including time of PiB (mean follow-up 10.8 years), with mean cortical DVR, age at baseline, sex, and education as independent predictors. Voxel-based analysis identified local associations. RESULTS: [(11)C]PiB retention was higher in older individuals. Greater declines over time in mental status and verbal learning and memory, but not visual memory, were associated significantly with higher PiB retention. Voxel-based analysis showed significant associations in frontal and lateral temporal regions. CONCLUSIONS: Higher Abeta deposition is associated with greater longitudinal decline in mental status and verbal memory in the preceding years. The differential association for verbal but not visual memory may reflect the greater reliance of verbal word list learning on prefrontal regions, which show early Abeta deposition. Prospective imaging may help distinguish between individuals with evolving neuropathology who develop accelerated cognitive decline vs those with normal aging.
Source: Neurology
Authors: S. M. Resnick, J. Sojkova, Y. Zhou, Y. An, W. Ye, D. P. Holt, R. F. Dannals, C. A. Mathis, W. E. Klunk, L. Ferrucci, M. A. Kraut, D. F. Wong
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Energy, Dana Foundation, Amgen, Bristol-Myers Squibb, Eli Lilly and Company, AstraZeneca, Sanofi, Johns Hopkins University, University of Pittsburgh, Orexigen Therapeutics, University of Cambridge, Elan, Otsuka Pharmaceutical, National Institutes of Health, Avid Radiopharmaceuticals, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Biomedical Imaging and Bioengineering
Awards: G100845555, G104586243, Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes, G1333555762, G1778830070, Mechanisms of Dopamine and Serotonin in Tourette Syndrome, Amyloid Imaging Agents for Position Emission Tomography, The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease, G2241124166, G2640555407, Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology, Alzheimer's Disease Research Center, G3131374986, G3146424788, G3177943049, G3553156159, G3710456697, Natural History of Amyloid Deposition in adults with Down Syndrome, G453267231, G5366509656, G5389965057, Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD, G6259281481, G6715061511, G707218699, G781725486, Human Imaging Research in Neuropsychiatry and Drug Abuse, G8287830055, AMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLY, G9000039018, G9000070217, G9000122335, G9000202499, G9000208814, G9000300274, ALZHEIMERS RESEARCH PROJECT: Neuroimaging Predictors of Alzheimer's Disease and Cognitive Decline, G920654007
OpenAlex ID: W1999367055