EFFECTS OF KETAMINE AND OF HIGH PRESSURE ON THE RESPONSES TO γ‐AMINOBUTYRIC ACID OF THE RAT SUPERIOR CERVICAL GANGLION in vitro
Year: 1982
Type: article
Abstract: 1 The method of Brown & Marsh (1974) for recording of surface potentials from the rat superior cervical ganglion has been adapted for use in a high pressure chamber in order to study the effects of high pressure of helium and the possible interactions with the effects of general anaesthetics. 2 Helium pressure of 130 atm did not alter the amplitude of the responses recorded from the ganglion in response to gamma-aminobutyric acid (GABA) application (9.7 and 19.4 microM) but the amplitude of responses to a nicotinic agonist were depressed. 3 Ketamine, at concentration between 18 and 180 microM, considerably potentiated the responses of the ganglion to GABA. 4 Helium pressure (130 atm) did not reverse the potentiation of GABA by ketamine. 5 The results are discussed in connection with the ability of ketamine to oppose the behavioural effects of high pressure.
Source: British Journal of Pharmacology
Author: HILARY J. LITTLE
Institution: University of Oxford
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1999400725