Work

mTOR-inhibitors may aggravate chronic hepatitis E

Year: 2014
Type: article
Abstract: Although hepatitis E virus (HEV) is a much understudied pathogen, it is one of the most important causes of acute hepatitis worldwide. Based on calculations for genotypes 1 and 2, an annual incidence of 20 million HEV infections resulting in about 70,000 deaths has been estimated [1]. These two genotypes are endemic in developing countries and cause large-scale water-borne outbreaks [2], such as the very recent outbreak in Nepal (www.promedmail.org; archive number: 20140509.2461705). A hallmark for such outbreaks is the high morbidity and mortality observed in pregnant women, with fatality rates up to 25%.
Language: English
Subfield: Hepatology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $5,500
OpenAlex ID: W1999518216
FWCI: 0.373
Cites: 24
Cited by: 7
Related to: 10