Work

CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

Year: 2003

Type: article

Abstract: Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

Source: British Journal of Cancer

DOI: 10.1038/sj.bjc.6601225

Authors: A G M Stam, S J A M Santegoets, T M Westers, C C Sombroek, J J W M Janssen, B W Tillman, A A van de Loosdrecht, H M Pinedo, D T Curiel, G J Ossenkoppele, R J Scheper, T D de Gruijl

Institutions: Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: DENDRITIC CELL SPECIFIC VECTOR, SPORE in Breast Cancer, Endothelial Gene Delivery for Pulmonary Hypertension, PRECLINICAL MODELS OF ORGAN & CELL TRANSPLANT TOLERANCE, G8311222247

OpenAlex ID: W1999554668

FWCI: 0.646

Cites: 12

Cited by: 14

Related to: 10