Work

Anti-CD45 Pretargeted Radioimmunotherapy Prior to Bone Marrow Transplantation without Total Body Irradiation Facilitates Engraftment From Haploidentical Donors and Prolongs Survival in a Disseminated Murine Leukemia Model

Year: 2013

Type: article

Abstract: In many cases the only curative treatment option for patients with advanced leukemias may be hematopoietic cell transplantation (HCT), which is often associated with toxicities. Despite HCT, patients still relapse while others will not have the option of HCT due to the unavailability of an HLA-matched donor. We aim to overcome these hurdles using anti-CD45 pretargeted radioimmunotherapy (PRIT) in lieu of total body irradiation (TBI) for haploidentical bone marrow transplantation (BMT). B6SJLF1/J mice were given 105 syngeneic myeloid leukemia cells followed by injection of anti-CD45 antibody (30F11; 140 μg) conjugated to streptavidin (SAv).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.277