Feasibility of CD34-Positive Stem Cell Mobilization by Administration of AMD3100 Six Hours Prior to Leukapheresis
Year: 2009
Type: article
Abstract: AMD3100, an inhibitor of the SDF-1 chemokine interaction with the CXCR4 receptor, has allowed successful mobilization of CD34 stem cells in patients with hematologic malignancies for whom traditional GCSF based mobilization regimens have failed. As part of a Compassionate Use Protocol (CUP), we have been able to collect adequate stem cells in seven such patients. Based on pharmacokinetic and pharmacodynamic data, the recommended time of the subcutaneous administration of 240 mcg/kg of AMD3100 is 10–11 hours before the start of apheresis (in addition to standard GCSF administration timing).
Authors: A. Chari, M. Vendivil, S. Clark-Garvey, J. Schwartz, R. Slotky, D. Diuguid, D. Savage
Institution: Columbia University Irving Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1999942534