Perspectives series: cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis.
Year: 1997
Type: article
Abstract: Cell Adhesion in Vascular BiologyLesions of atherosclerosis are only found in the intima, and the smooth muscle cells (SMC) 1 comprising these lesions are clonal.These two simple facts imply that formation of the intima, presumably by migration of cells from the media, is a key event in the early stages of atherosclerosis.There is also a lot of interest (1), although less data, in the possibility that smooth muscle migration and proliferation are critical in later stages of the disease and, particularly, in restenosis after angioplasty.This review will discuss possible critical roles for migration in the origin and progression of atherosclerotic lesions.
DOI: 10.1172/jci119472
Author: S M Schwartz
Institution: University of Washington
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1999983218