Work

The management of herpes simplex virus infections in HIV infected patients: current issues and the role of cidofovir

Year: 2011

Type: article

Abstract: : Herpes simplex virus (HSV) type 1 and 2 are among the most common transmitted viral infections causing a spectrum of mucocutaneous and other syndromes. Treatment of these infections has primarily been with acyclovir (ACV) and prodrugs valacyclovir and famcyclovir. Immunocompromised hosts either due to human immunodeficiency virus (HIV) or other factors have given rise to an increase in ACV resistant viruses most commonly due to a mutation in the cellular thymidine kinase enzyme. This review focuses on the spectrum of disease caused by HSV 1 and 2, the emergence of ACV resistant disease, and the role of alternative agents including cidofovir in the treatment of ACV resistant disease. Keywords: herpes simplex virus, HIV, resistance, cidofovir

Source: Virus Adaptation and Treatment

DOI: 10.2147/vaat.s12984

Authors: Steven Reynolds, Nakakawa

Institutions: National Institutes of Health, Johns Hopkins University, National Institute of Allergy and Infectious Diseases, Makerere University

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2000111795

FWCI: 0.432

Cites: 78

Cited by: 2

Related to: 10