Work

The Cytotoxic Action of Immune Gamma Globulin and Complement on Krebs Ascites Tumor Cells

Year: 1959

Type: article

Abstract: Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.109.5.505

Authors: Burton Goldberg, Howard Green

Institutions: Bellevue Hospital Center, New York University

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: U.S. Public Health Service