Work

A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy

Year: 2009

Type: article

Abstract: We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

Source: Nano Letters

DOI: 10.1021/nl901610f

Authors: Elena A. Rozhkova, Ilya Ulasov, Barry Lai, Nada M. Dimitrijevic, Maciej S. Lesniak, Tijana Rajh

Institutions: Argonne National Laboratory, University of Chicago, Advanced Photon Source, Center for Nanoscale Materials

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke