Work

TRB3 links ER stress to autophagy in cannabinoid antitumoral action

Year: 2009

Type: article

Abstract: Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.

Source: Autophagy

DOI: 10.4161/auto.5.7.9508

Authors: María Salazar, Arkaitz Carracedo, Íñigo J. Salanueva, Sonia Hernández-Tiedra, Ainara Egia, Mar Lorente, Patricia Vázquez, Sofia Torres, Juan L. Iovanna, Manuel Guzmán, Patricia Boya, Guillermo Velasco

Institutions: Universidad Complutense de Madrid, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2000201704

FWCI: 2.995

Cites: 1

Cited by: 76

Related to: 10