Work

Blockade of α6-Integrin Reveals Diversity in Homing Patterns Among Human, Baboon, and Murine Cells

Year: 2008

Type: article

Abstract: Our understanding of the mechanisms by which intravenously transplanted hematopoietic stem/progenitor cells (HSPCs) home to and engraft the bone marrow (BM) remains incomplete, but participation of adhesion molecules has been documented. We here demonstrate that blockade of the alpha6-integrin enhanced BM homing of human and nonhuman primate BM-derived HSPCs by >60% in the xenogeneic transplant model and led to significantly improved engraftment. The effect was limited to BM-derived HSPCs, as granulocyte-colony-stimulating factor mobilized peripheral blood or cord blood HSPCs express little or no alpha6 integrin. By contrast, despite high alpha6 integrin expression, no effect of alpha6 blockade on murine BM-HSPCs homing/engraftment was observed.

Source: Stem Cells and Development

DOI: 10.1089/scd.2008.0269

Authors: Halvard Bonig, Gregory V. Priestley, Martin Wohlfahrt, Hans-Peter Kiem, Thalia Papayannopoulou

Institutions: Goethe University Frankfurt, University of Washington, German Red Cross, Fred Hutch Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Washington, National Heart, Lung, and Blood Institute