Work

Stabilization of Cytochrome P450j Messenger Ribonucleic Acid in the Diabetic Rat

Year: 1987

Type: article

Abstract: Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its level is elevated in ethanol- and acetone-treated rats as well as in diabetic rats induced by either streptozotocin or alloxan. Although P450j protein is substantially elevated by all inducing regimens, only in diabetic rats is P450j mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this mRNA increase is not due to transcriptional activation but is due to specific stabilization of the P450j mRNA.

Source: Molecular Endocrinology

DOI: 10.1210/mend-1-8-542

Authors: Byung J. Song, Tamihide Matsunaga, James P. Hardwick, Sang S. Park, Richard L. Veech, Chung S. Yang, Harry V. Gelboin, Frank J. Gonzalez

Institutions: Argonne National Laboratory, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, Rutgers New Jersey Medical School

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Energy, Keio University, National Institutes of Health, National Cancer Institute

Awards: G1719812184, G2123841078, G2151907443, G3620013422, G4364667842, G4474980469, G7811065844, Capture and Reduction of Metal Ions out of the  Environment by Biomolecular Systems

OpenAlex ID: W2000211178

FWCI: 12.92

Cites: 40

Cited by: 200

Related to: 10