Work

Transition-Metal-Free Catalytic Synthesis of 1,5-Diaryl-1,2,3-triazoles

Year: 2010

Type: article

Abstract: 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Source: Organic Letters

DOI: 10.1021/ol101568d

Authors: Sen W. Kwok, Joseph R. Fotsing, Rebecca J. Fraser, Valentin O. Rodionov, Valery V. Fokin

Institution: Scripps Research Institute

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Carbon-Heteroatom Bond-Forming Reactions