Prediagnostic Circulating Parathyroid Hormone Concentration and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). METHODS: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. RESULTS: In multivariate analyses [including adjustment for 25(OH)D concentration] with a priori defined cutoff points, high levels of serum PTH (≥65 ng/L) compared with medium PTH levels of 30-65 ng/L were associated with increased CRC risk (RR = 1.41, 95% CI: 1.03-1.93). In analyses by sex, the CRC risk was 1.77 (95% CI: 1.14-2.75) and 1.15 (95% CI: 0.73-1.84) in men and women, respectively (P(heterogeneity) = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03-2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72-2.01 (P(heterogeneity) = 0.21). Effect modification by various risk factors was examined. CONCLUSIONS: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. IMPACT: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.
Authors: Veronika Fedirko, Elio Riboli, H. Bas Bueno-de-Mesquita, Sabina Rinaldi, Tobias Pischon, Teresa Norat, Eugène H. J. M. Jansen, Fränzel J. B. van Duijnhoven, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Pierre Engel, Rudolf Kaaks, Birgit Teucher, Heiner Boeing, Brian Buijsse, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, Sabina Sieri, Paolo Vineis, Salvatore Panico, Domenico Palli, Rosario Tumino, Carla H. van Gils, Petra H. M. Peeters, Maria-Dolores Chirlaque, Aurelio Barricarte Gurrea, Laudina Rodríguez, Esther Molina-Montes, Miren Dorronsoro, Catalina Bonet, Richard Palmqvist, Göran Hallmans, Timothy J. Key, Konstantinos K Tsilidis, Kay-Tee Khaw, Isabelle Romieu, Kurt Straif, Petra A. Wark, Dora Romaguera, Mazda Jenab
Institutions: Inserm, University of Cambridge, Institut Gustave Roussy, University of Oxford, Centre de recherche en Epidémiologie et Santé des Populations, National Institute for Public Health and the Environment, Imperial College London, Academy of Athens, Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto per lo Studio e la Prevenzione Oncologica, Centro de Investigación Biomédica en Red
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G1879609048
OpenAlex ID: W2000385033