Work

Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury

Year: 1998

Type: article

Abstract: Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.

Source: Brain Research

DOI: 10.1016/s0006-8993(98)00247-9

Authors: Lorraine A. DeGiorgio, Christine Dibinis, Teresa A. Milner, Makoto Saji, Bruce T. Volpe

Institutions: Cornell University, Burke Medical Research Institute, Tottori University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360