Treatment with Antibiotics Containing Activity Against Obligate Anaerobes Worsens GVHD Survival in Mice and Humans after Allogeneic BMT
Year: 2015
Type: article
Abstract: A relationship between the microbiota and GVHD has long been suspected but is still not well understood. We treated healthy 129S1 mice with either antibiotics (ABX) that included significant activity against anaerobic bacteria (piperacillin-tazobactam; pip-tazo, imipenem-cilastatin; imipenem or ones with reduced activity (cefepime, aztreonam). Mice were treated by s.c. injections of each antibiotic twice a day for two days and stool samples were collected, followed by 16S rRNA gene amplification and sequence analysis.
Institutions: Memorial Sloan Kettering Cancer Center, Keio University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2000524568