Work

Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat

Year: 1992

Type: article

Abstract: Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.

Source: Pharmacology Biochemistry and Behavior

DOI: 10.1016/0091-3057(92)90481-t

Authors: Ann C. Zmitrovich, Donald E. Hutchings, Diana L. Dow-Edwards, Daniel Malowany, Sarah Church

Institution: New York State Psychiatric Institute

Language: English

Topic: Prenatal Substance Exposure Effects

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650