Work

Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload

Year: 2010

Type: review

Abstract: The influence of iron on immune function has been long appreciated. However, the molecular basis for this interaction is less well understood. Recently, there have been several important advances that have shed light on the mechanisms that regulate mammalian iron metabolism. The new insights provide a conceptual framework for understanding and manipulating the cross-talk between iron homeostasis and the immune system. This article will review what is currently known about how disturbances of iron metabolism can affect immunity and how activation of the immune system can lead to alterations in iron balance.

Source: Archivum Immunologiae et Therapiae Experimentalis

DOI: 10.1007/s00005-010-0095-9

Author: Bobby J. Cherayil

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases