Work

Origin of late phase histamine release

Year: 1996

Type: article

Abstract: The early response to antigen precedes the onset of a chronic inflammatory response that includes the late reaction, defined as the recurrence of symptoms and mediator release hours later. We hypothesized that during the late-phase nasal response to antigen provocation, released histamine originates from basophils, on the basis of the pattern of mediator release.1 We subsequently showed the presence of basophils in the late reaction2 but could not exclude mast cells as a source of histamine release.

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/s0091-6749(96)70118-5

Authors: Robert M. Naclerio, Walter Hubbard, Lawrence M. Lichtenstein, Anne Kagey-Sobotka, David Proud

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,900