Work

Theoretical and Experimental Evidence for Hysteresis in Cell Proliferation

Year: 2003

Type: article

Abstract: We propose a mathematical model for the regulation of the G1-phase of the mammalian cell cycle taking into account interactions of cyclin D/cdk4, cyclin E/cdk2, Rb and E2F. Mathematical analysis of this model predicts that a change in the proliferative status in response to a change in concentrations of serum growth factors will exhibit the property of hysteresis: the concentration of growth factors required to induce proliferation is higher than the concentration required to maintain proliferation. We experimentally confirmed this prediction in mouse embryonic fibroblasts in vitro. In agreement with the mathematical model, this indicates that changes in proliferative mode caused by small changes in concentrations of growth factors are not easily reversible. Based on this study, we discuss the importance of proliferation hysteresis for cell cycle regulation.

Source: Cell Cycle

DOI: 10.4161/cc.2.1.186

Authors: Shaochun Bai, David Goodrich, C. Dennis Thron, Edwin Tecarro, Mandri Obeyesekere

Institutions: Roswell Park Comprehensive Cancer Center, University of St. Thomas - Texas, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: G3617956569