Work

Multi-component nanorods for vaccination applications

Year: 2005

Type: article

Abstract: Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CD8 T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.

Source: Nanotechnology

DOI: 10.1088/0957-4484/16/4/025

Authors: A K Salem, C F Hung, T W Kim, T C Wu, P C Searson, K W Leong

Institutions: University of Iowa, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Defense Advanced Research Projects Agency, Air Force Office of Scientific Research