Work

Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors

Year: 2015

Type: article

Abstract: We improved the migration and survival of chimeric antigen receptor (CAR)-modified T cells in solid tumors by combining CAR-T cells with an armed oncolytic virus. Local delivery of the chemokine RANTES and the cytokine IL-15 by the oncolytic virus enhanced the trafficking and persistence of the CAR-T cells, resulting in improved antitumor effects.

Source: OncoImmunology

DOI: 10.4161/21505594.2014.988098

Authors: Nobuhiro Nishio, Gianpietro Dotti

Institution: Baylor College of Medicine

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913