Work

Innovative multimodal DOTA/NODA nanoparticles for MRI and PET imaging for tumor detection

Year: 2014

Type: article

Abstract: The knowledge of the exact tumor stage is essential to adapt therapeutic strategies or to follow the evolution of the tumor after therapy in order to increase the survival chance. The multi-tasking diagnostics that combine techniques such as PET and MRI could really improve imaging tumor stage. PET mainly offers functional information about the disease with high sensitivity. MRI offers predominantly morphological infor-mation, able to provide an excellent soft tissue contrasts due to its high resolution. In this setting, we propose a polysiloxane nanoplatform gadolinium-based (AGuIX®) inferior to 5 nm able to combine PET/MRI imaging for tumor detection [1]. The size of this multimodal platform allows a good renal clearance [2]. The nanoparticles are composed of silica matrix functionalized by gadolinium chelate (DOTAGA-Gd), MRI positive contrast agent and free chelate (DOTAGA and NODAGA) for radiolabelling with isotopic radioactive such as 64Cu and 68Ga [3]. 68Ga isotope is an excellent candidate for nuclear imaging because of its availability. 64Cu has a long lifetime and can be used for Brachytherapy. Physical and chemical properties of the AGuIX ® coupled with 2,2’,2’’-(10-(2,6-dioxotetra hydro-2H-pyran-3-yl)-1,4,7,10-tet-

Source: EJNMMI Physics

DOI: 10.1186/2197-7364-1-s1-a80