Work

Physico-chemical and microbiological comparison of nystatin, amphotericin A and amphotericin B, and structure of amphotericin A.

Year: 1985

Type: article

Abstract: Two polyene antibiotics, nystatin and amphotericin A, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular weight, 926, by plasma desorption and electron-impact MS. However, 13C NMR spectrometry and HPLC studies indicated that the two molecules are different. The 200 MHz NMR studies indicated a chemical environment of 24 carbons of amphotericin A identical with that of the carbons of amphotericin B and nystatin. The structure of amphotericin A is identical with that of amphotericin B, except that there is a single bond between carbons 28 and 29 instead of a double bond, as shown by two-dimensional NMR studies.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.38.1699

Authors: A. ASZALOS, A. BAX, N. BURLINSON, P. ROLLER, C. MCNEAL

Institutions: United States Food and Drug Administration, Food and Drug Administration, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of British Columbia, National Cancer Institute, Texas A&M University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2000969584

FWCI:

Cites: 22

Cited by: 30

Related to: 10