Work

Partial maturation and robust ex vivo expansion of Umbilical Cord Blood (UCB) T cells: A step towards adoptive immunotherapy after UCB transplants

Year: 2006

Type: article

Abstract: Background: Viral infections cause significant morbidity and mortality in patients receiving unrelated umbilical cord blood (uUCB) transplants as there is no established antiviral immunity in naive UCB lymphocytes available for adoptive transfer. Additionally, UCB T cells lack Th1/Tc1 cytokines, granzymes, and perforin, which are prerequisites to control viral pathogens. Another limitation of UCB transplantation is the unavailability of donor T cells for post-transplant donor leukocyte infusions (DLI) to boost immunity or induce GVL.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.312

Authors: M.A. Mazur, Y.A. Lee, J. Kurtzburg, P. Szabolcs

Institution: Duke Medical Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650