Summary Measures of Adherence Using Pill Counts in Two HIV Prevention Trials: The Need for Standardisation in Reporting
Year: 2013
Type: article
Abstract: For trials of user-dependent HIV prevention products, accurate adherence measurements are essential to interpret and compare results across trials. We used pill count data from two recent HIV prevention trials of herpes simplex virus type 2 (HSV-2) suppression, to show that estimates of adherence vary substantially depending on assumptions that are made in analysing pill count data. We associate calculated adherence with biological markers of anti-HSV-2 activity. In both trials, calculated adherence varied considerably, depending on the summary measure used, and the handling of intervals with apparent 'over-adherence' (fewer pills returned than expected), and unreturned pills. Intervals of apparent over-adherence were associated with reduced antiviral effects on biological markers of herpes reactivation, indicating these are likely to represent periods of non-adherence. Our results demonstrate the clear need for standardisation in reporting of adherence data that are based on pill counts.
Source: AIDS and Behavior
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,590
Awards: Delivery of integrated PrEP and ART for HIV prevention for couples in Kenya, HIV PREVENTION TRIALS NETWORK LEADERSHIP GROUP, G2100077283, G2162672948, G2767126187, Clinical Epidemiology and Pathogenesis of Asymptomatic HSV, G3236979474, Clinical epidemiology of HSV-2 and the impact of interventions against sexually transmitted infections to reduce HIV incidence in high risk women from gold mining communities in Tanzania., Acyclovir to Prevent HIV Acquisition in HSV-2+ Persons, G7033575271, G8872134145, G9000057394
OpenAlex ID: W2001064065