Work

Treatise on the Measurement of Molecular Masses with Ion Mobility Spectrometry

Year: 2009

Type: article

Abstract: The ability to separate isotopes by high-resolution ion mobility spectrometry techniques is considered as a direct means for determining mass at ambient pressures. Calculations of peak shapes from the transport equation show that it should be possible to separate isotopes for low-mass ions (<200) by utilizing heavy collision gases and high-resolution ion mobility analyzers. The mass accuracy associated with this isotopic separation approach based on ion mobility separation is considered. Finally, we predict several isotopes that should be separable.

Source: Analytical Chemistry

DOI: 10.1021/ac900255a

Authors: Stephen J. Valentine, David E. Clemmer

Institutions: Indiana University Bloomington, Indiana University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Lilly Endowment, National Institutes of Health, National Institute on Aging, National Center for Research Resources

Awards: G1491813722, G3737267692, New proteome technologies: mapping adult D. melanogaster, Biomed Studies & Instrumentation in Proteomics/Glycomics